Research
Energy balance
Metabolic adaptations to weight loss (e.g., decreased energy expenditure) act to resist weight change and contribute to weight regain.
Expect metabolic adaptations when losing weight. These adaptations resist weight change and contribute to regain, making sustained weight loss challenging.
StrongSupportsHIGH confidence
These metabolic adaptations act to resist weight change and have been hypothesized to play a role in weight regain after loss.
Why this rating
Based on empirical evidence.
Source
DynamicInterplayAmongHomeostatic,Hedonic,and CognitiveFeedbackCircuitsRegulatingBodyWeight
Kevin D. Hall et al. · RePEc: Research Papers in Economics · 2014
DOI 10.2105/ajph.2014.301931_6
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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