Research
Mixed
Combining obesity management medications (OMM) with metabolic bariatric surgery (MBS) or endoscopic procedures is an inevitable and necessary component of future personalized obesity care, though optimal protocols are currently undefined.
Future obesity care will likely involve combining medications (like GLP-1s) with surgery or endoscopy. This combination is becoming standard to manage weight regain or suboptimal responses, though specific dosing and timing protocols are still being researched.
ModerateSupportsMEDIUM confidence
As such, it is inevitable that for some people with obesity, the optimal treatment plan will include, concomitantly or sequentially, obesity management medications (OMM) and metabolic bariatric surgical (MBS) or endoscopic procedures.
Why this rating
Based on expert consensus and limited RCTs (GRAVITAS, BARI-OPTIMISE), not large-scale definitive trials.
Source
The Future of Obesity Care: Exploring Synergies Between Metabolic Bariatric Surgery, Interventional Endoscopy and Pharmacotherapy
Wendy A. Brown et al. · Obesity Surgery · 2026
DOI 10.1007/s11695-026-08692-4
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- New generation obesity medications (GLP-1/GIP agonists) achieve mean weight loss of 15–25% over 68–72 weeks, narrowing the efficacy gap between medical and surgical management of obesity.Good
- Post-bariatric surgery weight regain (affecting 15-20% of patients) can be managed with endoscopic interventions or OMM, but optimal dosing and scheduling for these combination therapies remain undefined.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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