Research
Energy balance
SGLT2 inhibitors reduce systemic inflammation and oxidative stress by decreasing body fat mass and improving insulin resistance, which lowers inflammatory markers like IL-6 and TNF-alpha.
By helping you lose weight through sugar excretion, SGLT2 inhibitors reduce the inflammation that damages blood vessels, offering protection beyond just lowering blood sugar.
GoodSupportsHIGH confidence
Improved insulin resistance, along with decreased body fat mass associated with SGLT2 inhibitor treatment is consistent with previously well-established factors contributing to the prevention of CVD. These factors are responsible for reduction of oxidative stress as well as improvement of systemic inflammation.
Why this rating
Supported by animal models and clinical observations of reduced inflammatory markers.
Source
The Potential Cardioprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors
Jae‐Han Jeon · Journal of Korean Diabetes · 2019
DOI 10.4093/jkd.2019.20.2.81
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- SGLT2 inhibitors protect kidney function by restoring tubuloglomerular feedback, which reduces glomerular hyperfiltration and intraglomerular pressure, thereby indirectly reducing cardiovascular disease risk.Good
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