Mixed
Contrast-enhanced ultrasound (CEUS) using gamma variate modeling of bolus microbubble injection provides a valid, noninvasive, and reproducible method for quantifying skeletal muscle microvascular perfusion in vivo.
If you are researching vascular health in older adults or those with metabolic disease, use Contrast-Enhanced Ultrasound (CEUS) with gamma variate modeling. This method allows you to see exactly how well blood flows into skeletal muscle at rest and during exercise, offering a much clearer picture of health than standard artery stiffness tests alone.
CEUS is a promising, noninvasive imaging technique... CEUS could be used to compliment any macrovascular assessments to capture a more complete picture of the aging vasculature, and the modified methods presented here provide a template for the general analysis of CEUS within a research setting.
Why this rating
The paper presents a methodological validation with excellent interrater/intrarater reliability (ICC > 0.9) in a small sample (n=2), but lacks large-scale clinical outcome data.
Source
Cardiovascular aging and the microcirculation of skeletal muscle: using contrast-enhanced ultrasound
Emily C. Dunford et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2018
DOI 10.1152/ajpheart.00737.2017
Related findings · Mixed
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