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Long-term intentional weight loss via intensive lifestyle intervention causes greater bone mineral density loss at the hip in men with type 2 diabetes compared to control, increasing frailty fracture risk.

If you have type 2 diabetes and are planning to lose weight, be aware that men may experience greater bone loss at the hip over the long term. To mitigate this, ensure your weight loss plan includes bone-preserving strategies such as resistance training, adequate calcium and vitamin D intake, and regular monitoring of bone density, rather than relying solely on caloric restriction and walking.

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Long term intentional weight loss was associated with greater bone loss at the hip in men. These results taken with the previously published Look AHEAD data from the entire clinical trial showing increased frailty fracture risk with weight loss in the ILI group suggest that when intentional weight loss is planned, consideration of bone density preservation and fracture prevention strategies is warranted.
Karen Johnson et al. · Archives of Osteoporosis · 2023

Why this rating

Randomized clinical trial with long-term follow-up (up to 16 years), though limited to a DXA substudy subset.

Source

The long-term effect of intentional weight loss on changes in bone mineral density in persons with type 2 diabetes: results from the Look AHEAD randomized trial

Karen Johnson et al. · Archives of Osteoporosis · 2023

DOI 10.1007/s11657-023-01303-0

rct · n=808Cited 12×
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DOI resolved against Crossref · corpus check 2026-06-10

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