Micronutrients & recovery

Fat cell size (FCS) is the strongest independent determinant of baseline insulin sensitivity in overweight subjects, and its reduction is correlated with improved insulin sensitivity, although it is not an independent predictor of Si improvement after weight loss.

While losing visceral fat is key for improving insulin sensitivity, the health of your subcutaneous fat cells (their size) is a major factor in your baseline metabolic state. Large fat cells are associated with insulin resistance. Weight loss reduces fat cell size, which is part of the mechanism for improved health, though the total amount of fat lost (especially visceral) is the primary driver of the improvement.