Energy balance
Gelesis100, a nonsystemic superabsorbent hydrogel taken orally before meals, produces statistically significant greater weight loss compared to placebo in adults with overweight or obesity.
Take three 2.25g capsules of Gelesis100 with 500ml of water 20-30 minutes before your two main meals. Combine this with a modest caloric deficit (300 kcal/day) and 30 minutes of daily walking. Expect about 6.4% weight loss over 24 weeks, which is statistically better than placebo but requires strict adherence to the timing and hydration instructions.
Gelesis100 treatment caused greater weight loss over placebo (6.4% vs. 4.4%, P = 0.0007), achieving 2.1% superiority but not 3% super-superiority.
Why this rating
Randomized, double-blind, placebo-controlled pivotal study with a large sample size (n=436), though funded by the manufacturer.
Source
A Randomized, Double‐Blind, Placebo‐Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss
Frank L. Greenway et al. · Obesity · 2018
DOI 10.1002/oby.22347
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