Energy balance
Lorcaserin (10 mg twice daily) reduces body weight in overweight/obese adults primarily by decreasing energy intake, with no significant effect on energy expenditure or substrate oxidation.
Take lorcaserin (10 mg, twice daily) as prescribed. It works by reducing your appetite and energy intake, not by speeding up your metabolism. Expect weight loss to be driven by eating less, and understand that your body's energy expenditure will naturally decrease as you lose weight, which is a normal metabolic adaptation, not a failure of the drug.
Lorcaserin reduces body weight through reduced EI, not altered EE or RQ.
Why this rating
Double-blind, randomized, placebo-controlled trial with objective measures (respiratory chamber, DEXA), though limited to 56 days.
Source
Lorcaserin, A 5-HT<sub>2C</sub>Receptor Agonist, Reduces Body Weight by Decreasing Energy Intake without Influencing Energy Expenditure
Corby K. Martin et al. · The Journal of Clinical Endocrinology & Metabolism · 2010
DOI 10.1210/jc.2010-1848
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