Research
Energy balance
High-intensity lifestyle interventions are associated with a modest, statistically non-significant reduction in all-cause mortality (OR 0.86), though the point estimate suggests a potential benefit.
While high-intensity lifestyle interventions may reduce mortality, the evidence is not yet statistically definitive due to low death rates in trials. However, the observed 14% reduction is promising and aligns with other long-term health data.
ModerateQualifiesMEDIUM confidence
The ORs for mortality for weight loss interventions compared with the controls was 0.86 (95% CI 0.73 to 1.02), p=0.09.
Why this rating
Meta-analysis of RCTs, but limited by low mortality rates and short follow-up in many studies.
Source
Intensity and duration of lifestyle interventions for long-term weight loss and association with mortality: a meta-analysis of randomised trials
Navneet Singh et al. · BMJ Open · 2019
DOI 10.1136/bmjopen-2019-029966
Meta-analysis · 31 studiesCited 90×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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