Mixed
Sleeve gastrectomy and Roux-en-Y gastric bypass (RYGB) produce clinically equivalent long-term excess BMI loss, though RYGB yields significantly higher total weight loss and superior resolution of dyslipidemia.
If you are considering bariatric surgery, understand that both sleeve gastrectomy and Roux-en-Y gastric bypass provide similar long-term excess weight loss results. However, RYGB offers better improvement in cholesterol levels (dyslipidemia) and a lower risk of developing new acid reflux (GERD). Sleeve gastrectomy has a lower rate of minor complications. Your choice should be based on your existing health conditions, particularly whether you suffer from reflux, rather than the assumption that one surgery is strictly 'better' for weight loss.
Sleeve gastrectomy and Roux-en-Y gastric bypass had clinically comparable excess BMI loss according to the predefined definition for equivalence. However, Roux-en-Y gastric bypass showed significantly higher total weight loss and significant advantages in secondary outcomes, including dyslipidaemia and GERD
Why this rating
Phase III multicentre randomised controlled trial with 5-year follow-up and large sample size (n=628).
Source
Long-term effect of sleeve gastrectomy vs Roux-en-Y gastric bypass in people living with severe obesity: a phase III multicentre randomised controlled trial (SleeveBypass)
L. Ulas Biter et al. · The Lancet Regional Health - Europe · 2024
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