Research
Hormonal
In women with high waist circumference, low saturated fat intake combined with high fitness significantly preserves early-phase insulin secretion (DI30) compared to those with suboptimal lifestyle profiles.
For women with higher body weight, combining a diet lower in saturated fats with regular cardio exercise can significantly help maintain healthy insulin secretion. This protective effect is less pronounced in men, highlighting the importance of sex-specific lifestyle strategies.
GoodQualifiesHIGH confidence
In women, the decrease in DI30 caused by high WC was nearly halved with the optimal lifestyle profile; i.e. a significant difference between 207 and 142 (D 65) and a non-significant difference between 207 and 173 (D 34) were observed
Why this rating
Robust subgroup analysis in a large cohort, though cross-sectional.
Source
Diet, insulin secretion and insulin sensitivity – the Dose–Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199)
Harri M. Heikkilä et al. · British Journal Of Nutrition · 2014
DOI 10.1017/s0007114514002426
cross_sectional · n=1114Cited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- High cardiorespiratory fitness combined with low saturated fat intake attenuates the negative impact of high waist circumference on early-phase insulin secretion (DI30) in women.Good
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