Mixed
A high-protein total diet replacement (HP-TDR) with 40% protein increases total energy expenditure and induces negative fat balance compared to a control diet in healthy, normal-weight adults.
If you are healthy and normal weight, switching to a high-protein diet (around 40% of calories from protein) can increase your daily energy expenditure by about 80 calories and help your body burn more fat, even if you eat the same total number of calories as a standard diet. This suggests that high-protein diets may be more effective for fat loss than standard diets when calories are matched.
Compared with the CON diet, the HP-TDR produced higher total energy expenditure [(EE) 81 ± 82 kcal/d, P <0.001]... Moreover, a HP-TDR led to decreased energy (–112 ± 85 kcal/d; P <0.001), fat (–22 ± 20 g/d; P <0.001), and carbohydrate balances... These results suggest that a HP-TDR may promote fat loss compared with a conventional isocaloric diet.
Why this rating
High-quality randomized crossover design with whole-body calorimetry, but limited to healthy normal-weight adults and short duration (32h).
Source
A high-protein total diet replacement increases energy expenditure and leads to negative fat balance in healthy, normal-weight adults
Camila L. P. Oliveira et al. · American Journal of Clinical Nutrition · 2020
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