Mixed

A medically supervised weight management program combining complete meal replacement (82 kcal/g) with behavioral counseling produces a statistically significant average 5.8% weight loss at 5 years, with 35.2% of participants achieving ≥10% weight loss.

To achieve significant long-term weight loss, you need a structured program that combines a strict initial diet (like meal replacements) with ongoing behavioral support. This study shows that losing 5-10% of your body weight over 5 years is possible without surgery or drugs if you commit to weekly counseling and gradual transition to regular food. The key is not just the diet, but the long-term behavioral support and accountability.