Energy balance
Maintaining ≥ 7% weight loss at 1 year following a 12-week intensive lifestyle intervention (ILI) in patients with diabetes and obesity predicts sustained cardiometabolic improvements, including lower A1C and better lipid profiles, over 15 years.
For patients with diabetes and obesity, completing a structured lifestyle program and maintaining at least 7% of their body weight loss after one year is a critical milestone. This specific level of sustained weight loss is strongly associated with better long-term blood sugar control (A1C) and lipid profiles over 15 years, even if the initial intensive program ends. Focus on maintaining that initial loss rather than expecting continuous rapid weight loss.
ILI in real-world clinical practice that results in ≥ 7% weight loss at 1 year in patients with DM and obesity is associated with continued improvement in cardiometabolic outcomes at 15 years.
Why this rating
Longitudinal study with 15-year follow-up in a real-world setting, though lacking a control group and using LOCF for missing data.
Source
Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study
Abdelrahman Khater et al. · Journal of Diabetes · 2025
DOI 10.1111/1753-0407.70153
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