Research
Hormonal
Females experience significantly greater weight loss than males when treated with incretin-based obesity medications (Semaglutide and Tirzepatide).
If you are male, expect that your weight loss may be slower than that of female peers taking the same medication. This is a known biological response. Do not be discouraged; the medication still provides significant metabolic benefits and fat loss, even if the scale moves slower.
ModerateSupportsMEDIUM confidence
Females exhibited greater weight loss... females showed significantly greater weight loss than males in our subgroup analyses.
Why this rating
Observational subgroup analysis within a real-world study.
Source
Real-world effects of incretin-based Obesity medications on body composition
Rahila Bhatti et al. · Obesity Pillars · 2025
DOI 10.1016/j.obpill.2025.100229
cohort · n=269
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide produces significantly greater long-term total body weight loss and fat mass reduction compared to Semaglutide in real-world clinical practice, with effects becoming distinct after 6 months.Moderate
- Skeletal muscle mass can be preserved during significant weight loss induced by incretin-based medications if the patient adheres to a program involving twice-weekly strength training and adequate protein intake (60-90 g/day).Moderate
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