Research
Adherence
Skeletal muscle mass can be preserved during significant weight loss induced by incretin-based medications if the patient adheres to a program involving twice-weekly strength training and adequate protein intake (60-90 g/day).
To prevent muscle loss while losing weight with these medications, you must actively train. Perform strength training at least twice a week and ensure you are eating 60-90 grams of protein daily. This combination helps stabilize your muscle mass after the initial months of weight loss.
ModerateQualifiesMEDIUM confidence
Lifestyle interventions supported skeletal muscle mass preservation... patients were advised to increase the protein intake to 60–90 g/day and incorporating strength training at least twice a week.
Why this rating
Observational data from a real-world study.
Source
Real-world effects of incretin-based Obesity medications on body composition
Rahila Bhatti et al. · Obesity Pillars · 2025
DOI 10.1016/j.obpill.2025.100229
cohort · n=269
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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