Mixed
The Adaptive Ketogenic–Mediterranean Protocol (AKMP) significantly improves insulin resistance, remnant cholesterol, and body composition in adults with overweight or obesity over a 14-week period.
Follow a 14-week plan starting with very low carbs (≤20g/day) and high healthy fats (olive oil, fish) to reset insulin sensitivity and burn fat. After 12 weeks, gradually add back carbs (>100g/day) while maintaining a Mediterranean diet structure. Monitor your progress and adjust protein or calories if weight loss stalls.
In adults with overweight or obesity, the AKMP was associated with improvements in the glucose–insulin axis, atherogenic profile (RC, TG/HDL-c, TG), and body composition, while maintaining a favorable safety profile.
Why this rating
Single-arm pre-post cohort study; lacks a control group, limiting causal inference despite statistical significance.
Source
Adaptive Ketogenic–Mediterranean Protocol (AKMP) in Real Clinical Practice: 14-Week Pre–Post Cohort Study on Glucolipid Markers and Safety
Cayetano García-Gorrita et al. · Nutrients · 2025
DOI 10.3390/nu17223559
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