Research
Mixed
The metabolic syndrome is a cluster of risk factors that identifies individuals at increased lifetime risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes, but it is not an adequate tool for estimating short-term (10-year) cardiovascular risk.
Having metabolic syndrome means you are at higher risk for heart disease and diabetes over your lifetime, but it does not mean you will have a heart attack soon. Use standard risk calculators (like Framingham) to check your 10-year risk. Focus on lifestyle changes to lower your long-term risk, especially if you do not yet have diabetes.
StrongQualifiesVERY_HIGH confidence
The metabolic syndrome per se is not an adequate tool to estimate 10-year risk for CHD. Although patients with the metabolic syndrome are at higher lifetime risk, in the absence of diabetes they do not necessarily have a high 10-year risk.
Why this rating
Based on Framingham risk scoring data and multiple studies cited.
Source
Diagnosis and Management of the Metabolic Syndrome
Scott M. Grundy et al. · Circulation · 2005
DOI 10.1161/circulationaha.105.169404
clinical_guidelineCited 11,770×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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