Hormonal
Supplementation with omega-3 fatty acids (EPA and DHA) reduces systemic inflammation and clinical symptoms in autoimmune and inflammatory diseases by suppressing proinflammatory cytokines (IL-1, TNF, IL-6) and shifting eicosanoid production toward less inflammatory derivatives.
If you have an inflammatory or autoimmune condition, increasing your intake of EPA and DHA (found in fish oil) may help reduce inflammation and symptoms. This is achieved by suppressing proinflammatory cytokines like IL-1 and TNF. While dietary changes are beneficial, therapeutic doses often require supplementation to achieve sufficient levels in cell membranes.
Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases.
Why this rating
The paper cites multiple randomized controlled trials, meta-analyses, and animal studies, though it acknowledges heterogeneity in response.
Source
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
Artemis P. Simopoulos · Journal of the American College of Nutrition · 2002
DOI 10.1080/07315724.2002.10719248
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