Research
Mixed
Consuming 1-2 servings of fish per week (providing ~250 mg/d EPA+DHA) reduces the risk of coronary heart disease (CHD) death by 36% and total mortality by 17% in adults, with benefits outweighing risks from contaminants.
Eat 1-2 servings of fish per week, focusing on oily fish like salmon, sardines, or herring. This provides about 250mg of EPA+DHA daily, which is sufficient to significantly lower your risk of heart disease death and total mortality. You do not need to avoid fish due to contaminant fears if you vary your seafood choices.
WeakSupportsHIGH confidence
Modest consumption of fish (eg, 1-2 servings/wk), especially species higher in the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduces risk of coronary death by 36% (95% confidence interval, 20%-50%; P<.001) and total mortality by 17% (95% confidence interval, 0%-32%; P=.046)... Intake of 250 mg/d of EPA and DHA appears sufficient for primary prevention.
Why this rating
Based on pooled meta-analyses of randomized clinical trials and large prospective cohort studies.
Source
Fish Intake, Contaminants, and Human Health
Dariush Mozaffarian et al. · JAMA · 2006
DOI 10.1001/jama.296.15.1885
Meta-analysisCited 1,953×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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