Hormonal
High dietary glycemic load combined with low cereal fiber intake significantly increases the risk of non-insulin-dependent diabetes mellitus (NIDDM) in men, independent of other known risk factors.
To lower your risk of type 2 diabetes, focus on the quality of your carbohydrates rather than just cutting them out. Choose minimally refined grains (high cereal fiber) and avoid foods that spike blood sugar rapidly (high glycemic load). Combining high-fiber, low-glycemic foods is the most protective dietary strategy identified.
The combination of a high glycemic load and a low cereal fiber intake further increased the risk of NIDDM (RR = 2.17, 95% CI, 1.04-4.54) when compared with a low glycemic load and high cereal fiber intake.
Why this rating
Large prospective cohort (n=42,759), long follow-up (6 years), rigorous adjustment for confounders, but observational design limits causal certainty.
Source
Dietary Fiber, Glycemic Load, and Risk of NIDDM in Men
Jorge Salmerón et al. · Diabetes Care · 1997
DOI 10.2337/diacare.20.4.545
More from this paper
- Higher dietary glycemic index is positively associated with an increased risk of NIDDM in men, but this association is statistically significant only after adjusting for cereal fiber intake.Good
- Higher intake of cereal fiber is inversely associated with the risk of NIDDM in men, independent of other fiber types and dietary confounders.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →