Micronutrients & recovery
Orlistat, a gastrointestinal lipase inhibitor, provides modest additional weight loss (4-6% of initial weight) and improves weight maintenance when used as an adjunct to lifestyle modification in patients with type 2 diabetes who fail to lose 10% of initial weight.
If you struggle to lose 10% of your weight in the first 6 months despite your best efforts, ask your doctor about Orlistat. It blocks about 30% of dietary fat absorption, providing a modest additional boost (4-6% loss). It is not a magic bullet and requires strict adherence to a low-fat diet to minimize side effects. It is only recommended if you have not achieved significant weight loss through lifestyle changes alone.
Several RCTs of patients with type 2 diabetes found, at 1 year, that orlistat plus lifestyle modification induced a loss of ≥4% to 6% of initial weight, compared with 2% to 4% for placebo plus lifestyle change (74–76).
Why this rating
Supported by multiple RCTs cited in the text.
Source
The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It
Thomas A Wadden et al. · Obesity · 2006
DOI 10.1038/oby.2006.84
More from this paper
- Intentional weight loss of approximately 7% of initial body weight combined with moderate-to-vigorous physical activity (175 min/week) improves glycemic control, blood pressure, and lipid profiles in overweight individuals with type 2 diabetes.Good
- The use of liquid meal replacements (shakes and bars) for two meals and one snack daily significantly increases weight loss compared to conventional isocaloric diets in individuals with type 2 diabetes.Good
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →