Hormonal
Tirzepatide (5, 10, and 15 mg once weekly) achieves glycaemic targets (HbA1c < 7.0% and ≤ 6.5%) significantly faster than semaglutide 1 mg and insulin degludec in patients with type 2 diabetes.
If you have type 2 diabetes, starting tirzepatide will likely lower your blood sugar (HbA1c) to target levels faster than starting semaglutide 1 mg or insulin degludec, even though you start on a low dose. You will need to wait 4-20 weeks to reach your full maintenance dose depending on the strength chosen, but clinical targets are met sooner with tirzepatide than with the comparators.
The median time to achieve HbA1c < 7.0% (8.1 weeks with each tirzepatide dose, 12.0 weeks with semaglutide 1 mg, and 12.1 weeks with insulin degludec) and ≤ 6.5% (12.1, 15.7, and 24.1 weeks, respectively) was faster with tirzepatide than semaglutide 1 mg and insulin degludec.
Why this rating
Based on pre-planned exploratory analysis of two large, randomized Phase 3 trials (SURPASS-2 and SURPASS-3) with robust statistical methods (Cox proportional-hazards).
Source
Time to Reach Glycaemic and Body Weight Loss Thresholds with Tirzepatide in Patients with Type 2 Diabetes: A Pre-planned Exploratory Analysis of SURPASS-2 and SURPASS-3
Adie Viljoen et al. · Diabetes Therapy · 2023
DOI 10.1007/s13300-023-01398-1
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