Research
Adherence
Modest lifestyle modifications (diet, physical activity, weight loss, smoking cessation) have the greatest impact on reversing obesity and its metabolic consequences compared to pharmacologic interventions.
Prioritize modest, sustainable lifestyle changes over medication. Focus on reducing caloric intake, increasing physical activity, and quitting smoking. These changes address the root cause and have the greatest health impact.
GoodSupportsHIGH confidence
Current and future pharmacologic interventions may target these pathways; modest changes in diet, physical activity, weight, and smoking are likely to have the greatest impact.
Why this rating
Based on a review of pathophysiology and clinical implications, supported by references to trials.
Source
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
Sarah D. de Ferranti et al. · Clinical Chemistry · 2008
narrative_reviewCited 728×
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