Hormonal
In Asian Indian men with normal BMI, visceral adipose tissue volume is the primary determinant of insulin resistance, whereas subcutaneous fat and total body fat are not significant predictors when visceral fat is controlled.
If you are an Asian Indian male with a normal BMI, do not assume you are metabolically healthy. Your risk for insulin resistance and diabetes is driven by visceral fat, which standard weight metrics miss. You should prioritize metabolic screening (like fasting insulin or glucose) and lifestyle interventions that target visceral fat reduction, such as aerobic exercise and dietary quality, rather than focusing solely on scale weight.
Only visceral adipose tissue volume was significantly (P < 0.005) related to insulin-mediated glucose disposal and explained 38% of the variance... The nonsignificant (both P > 0.32) terms (total and abdominal sc adipose tissue volume) explained an additional 3% of the variance.
Why this rating
Study uses gold-standard euglycemic insulin clamp and CT scanning, but is observational and limited to a specific ethnic subgroup (n=20).
Source
Body Composition, Visceral Fat, Leptin, and Insulin Resistance in Asian Indian Men<sup>1</sup>
Mary Ann Banerji et al. · The Journal of Clinical Endocrinology & Metabolism · 1999
DOI 10.1210/jcem.84.1.5371
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