Mixed
High consumption of sugar-sweetened beverages (≥1 serving/day) significantly amplifies the genetic predisposition to obesity and increases BMI more than low consumption (<1 serving/month) in individuals with a high genetic risk score.
If you have a family history of obesity, your body is likely more sensitive to the effects of sugary drinks. Cutting out sugar-sweetened beverages is not just a general health tip for you; it is a specific, high-impact intervention to counteract your genetic risk. Avoiding these drinks can significantly blunt the genetic drive toward weight gain.
In the combined cohorts, the increases in BMI per increment of 10 risk alleles were 1.00 for an intake of less than one serving per month... and 1.78 for one or more servings per day (P<0.001 for interaction).
Why this rating
Large prospective cohorts (NHS, HPFS, WGHS) with replication, though observational design limits causal inference compared to RCTs.
Source
Sugar-Sweetened Beverages and Genetic Risk of Obesity
Qibin Qi et al. · New England Journal of Medicine · 2012
DOI 10.1056/nejmoa1203039
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