Research

Mixed

Increasing dietary intake of marine n-3 fatty acids or fish consumption from low levels (1 serving/month) to high levels (6+ servings/week) does not substantially reduce the risk of coronary heart disease in men without preexisting cardiovascular disease.

If you are a healthy man, eating more fish (up to 6 servings a week) or increasing your marine n-3 fatty acid intake is unlikely to significantly lower your risk of coronary heart disease. While fish is part of a healthy diet, this study suggests that dietary amounts are insufficient to provide the protective cardiovascular effects often attributed to fish oil supplements, which require much higher doses.

GoodRefutesHIGH confidence
these data suggest that increasing fish intake from one to two servings per week to five to six servings per week does not substantially reduce the risk of coronary heart disease among men who are initially free of cardiovascular disease.
Alberto Ascherio et al. · New England Journal of Medicine · 1995

Why this rating

Large prospective cohort study (n=44,895) with long follow-up (6 years) and rigorous adjustment for confounders, though observational design limits causal inference.

Source

Dietary Intake of Marine n-3 Fatty Acids, Fish Intake, and the Risk of Coronary Disease among Men

Alberto Ascherio et al. · New England Journal of Medicine · 1995

DOI 10.1056/nejm199504133321501

cohort · n=44895Cited 548×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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