Research
Energy balance
Modest weight gain (4-10 kg) during adulthood significantly increases the risk of coronary heart disease, independent of physical activity levels.
Even small weight gains of 4-10 kg during adulthood can increase your risk of heart disease. This risk exists even if you are physically active. Maintaining a stable weight is an important part of heart health prevention.
StrongSupportsVERY_HIGH confidence
Even a modest weight gain (4 to 10 kg) during adulthood was associated with 27% (95% CI, 12% to 45%) increased risk of CHD compared with women with a stable weight after adjusting for physical activity and other cardiovascular risk factors.
Why this rating
Large cohort, long follow-up, adjustment for confounders.
Source
Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women
Tricia Y. Li et al. · Circulation · 2006
DOI 10.1161/circulationaha.105.574087
cohort · n=88393Cited 479×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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