Research
Hormonal
Bariatric surgery is the most efficacious treatment for sustained weight loss and can induce long-term remission of type 2 diabetes in approximately 30% of patients, with Roux-en-Y gastric bypass being potentially more effective than sleeve gastrectomy for T2D remission.
For severe obesity, bariatric surgery is the most effective long-term treatment. It can lead to remission of type 2 diabetes in about 30% of patients and reduces the risk of heart disease and stroke. It is a serious medical intervention, not a cosmetic procedure.
GoodSupportsHIGH confidence
Bariatric surgery is the most efficacious treatment for sustained weight loss... It can cause long-term remission of T2D in ~30% of patients... Roux-en-Y gastric bypass may be more efficacious than sleeve gastrectomy for T2D remission.
Why this rating
Supported by observational data and clinical trials, but long-term data varies.
Source
Obesity as a <scp>multisystem</scp> disease: Trends in obesity rates and <scp>obesity‐related</scp> complications
Shohinee Sarma et al. · Diabetes Obesity and Metabolism · 2021
DOI 10.1111/dom.14290
narrative_reviewCited 405×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Modest weight loss (5-10%) prevents type 2 diabetes in high-risk individuals, while greater weight loss (>10-15%) can induce remission of established type 2 diabetes, particularly when intervention occurs early in the disease course.Strong
- Obesity is a multisystem disease where excess adiposity causes comorbidities across multiple organ systems (cardiovascular, metabolic, malignancy, mental health), and weight loss can prevent or reverse many of these conditions.Strong
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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