Research
Macro partitioning
High intake of refined carbohydrates and high glycemic index foods promotes oxidative stress and chronic inflammation via NF-κB-mediated signaling, contributing to insulin resistance and metabolic syndrome.
Focus on reducing refined carbohydrates and high glycemic index foods (like white rice and added sugars) to lower oxidative stress and inflammation. Opt for lower glycemic index options to help manage blood sugar and metabolic health, especially if you are overweight or have metabolic syndrome.
GoodSupportsHIGH confidence
Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF-κB-) mediated cell signaling pathways. Dietary carbohydrates are important to highlight here because they may contribute to the long-term consequences of nutritionally mediated inflammation.
Why this rating
The paper cites multiple observational, cohort, and animal studies linking high GI/refined carbs to metabolic issues, though it acknowledges complex mechanisms.
Source
Nutrients and Oxidative Stress: Friend or Foe?
Bee Ling Tan et al. · Oxidative Medicine and Cellular Longevity · 2018
narrative_reviewCited 383×
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