Macro partitioning
Higher circulating and tissue levels of linoleic acid (LA), the primary dietary omega-6 fatty acid, are associated with a significantly lower risk of total cardiovascular disease, cardiovascular mortality, and ischemic stroke.
Focus on maintaining healthy levels of linoleic acid (LA) through your diet, as higher biomarker levels of LA are linked to lower risks of heart disease and stroke. This suggests that current dietary guidelines recommending omega-6 intake are supported by large-scale evidence, and you do not need to fear omega-6 fatty acids for causing heart disease.
Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88–0.99), 0.78 (0.70–0.85), and 0.88 (0.79–0.98), respectively
Why this rating
Large-scale pooled individual-level analysis of 30 prospective studies (n=68,659) with harmonized protocols minimizes bias and increases statistical power.
Source
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality
Matti Marklund et al. · Circulation · 2019
DOI 10.1161/circulationaha.118.038908
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