Research
Macro partitioning
Higher circulating and tissue levels of arachidonic acid (AA) are not associated with an increased risk of cardiovascular disease, and may be associated with a lower risk of total CVD.
You do not need to worry about high levels of arachidonic acid (AA) in your blood as a risk factor for heart disease. This study shows that higher AA levels are not associated with increased CVD risk and may even be linked to lower risk.
StrongRefutesHIGH confidence
AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86–0.99).
Why this rating
Large-scale pooled analysis provides robust evidence against the harm hypothesis of AA.
Source
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality
Matti Marklund et al. · Circulation · 2019
DOI 10.1161/circulationaha.118.038908
Meta-analysis · 30 studiesCited 326×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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