Hormonal
Elevated baseline plasma ceramide concentrations are positively associated with an increased risk of incident cardiovascular disease (CVD), including myocardial infarction, stroke, and cardiovascular death.
High plasma ceramide levels are linked to a higher risk of heart attacks, strokes, and cardiovascular death. However, this risk is not fixed; adhering to a Mediterranean diet (enriched with olive oil or nuts) can neutralize the increased risk associated with high ceramide levels, bringing it down to the level of those with low ceramide levels.
Our study documented a novel positive association between baseline plasma ceramide concentrations and incident CVD.
Why this rating
Prospective case-cohort design nested within a large, well-known randomized controlled trial (PREDIMED) with rigorous statistical adjustment.
Source
Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)
Dong D. Wang et al. · Circulation · 2017
DOI 10.1161/circulationaha.116.024261
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