Macro partitioning
A Mediterranean diet supplemented with extra virgin olive oil or nuts mitigates the deleterious effect of elevated plasma ceramide concentrations on cardiovascular disease risk, effectively neutralizing the increased risk associated with high ceramide levels.
If you have high ceramide levels, switching to a Mediterranean diet rich in olive oil or nuts can effectively cancel out the increased heart disease risk associated with those levels. This dietary pattern brings your risk down to the same level as people with naturally low ceramide levels.
Participants with a higher ceramide score and assigned to either of the 2 active intervention arms of the trial showed similar CVD risk to those with a lower ceramide score
Why this rating
Randomized controlled trial design with long-term follow-up and rigorous statistical handling of interaction effects.
Source
Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)
Dong D. Wang et al. · Circulation · 2017
DOI 10.1161/circulationaha.116.024261
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