Mixed
Orlistat (120 mg three times daily) combined with a reduced-calorie diet produces significantly greater weight loss and improvements in glycemic control (HbA1c) and cardiovascular risk factors compared to diet and placebo alone in overweight or obese patients with insulin-treated type 2 diabetes.
If you have type 2 diabetes and take insulin, adding Orlistat (120mg with meals) to a calorie-controlled diet can help you lose more weight and improve your blood sugar control compared to diet alone. This often allows for a reduction in your insulin dose. Be prepared for potential gastrointestinal side effects, which are usually mild, and ensure you follow the low-fat diet guidelines to minimize them.
Orlistat therapy produces clinically significant weight loss, with improvements in glycemic control and cardiovascular disease risk factors, in overweight or obese patients with type 2 diabetes who have suboptimal metabolic control with insulin therapy.
Why this rating
Randomized, double-blind, placebo-controlled multicenter trial with a large sample size (n=550) and statistically significant results.
Source
Clinical Efficacy of Orlistat Therapy in Overweight and Obese Patients With Insulin-Treated Type 2 Diabetes
David E. Kelley et al. · Diabetes Care · 2002
DOI 10.2337/diacare.25.6.1033
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →