Research
Energy balance
Lower-body fat (LBF) is associated with more favorable left ventricular contractility, potentially acting as a metabolic sink that protects against ectopic fat deposition.
While reducing visceral fat is critical, having some lower-body fat may offer metabolic protection by storing excess lipids safely. However, this benefit is overshadowed by high visceral fat.
ModerateSupportsMEDIUM confidence
Higher LBF was associated with lower Ecc suggesting more favorable LV contractility after adjustment for CVD risk factors, CRF, and LV parameters
Why this rating
Association is lost in the most adjusted model (Model 4) when VAT is included.
Source
Regional adiposity, cardiorespiratory fitness, and left ventricular strain: an analysis from the Dallas Heart Study
Nitin Kondamudi et al. · Journal of Cardiovascular Magnetic Resonance · 2021
DOI 10.1186/s12968-021-00757-w
cross_sectional · n=1089Cited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Higher visceral adipose tissue (VAT) is independently associated with greater impairment in left ventricular peak circumferential strain (Ecc), indicating reduced myocardial contractility, regardless of cardiorespiratory fitness (CRF) or other regional fat depots.Good
- Higher cardiorespiratory fitness (CRF) is independently associated with more favorable left ventricular contractility (lower Ecc), independent of visceral fat levels and other risk factors.Good
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