Mixed
Post-diagnosis weight loss of >10 kg is associated with a 2.66 times greater all-cause mortality compared to maintaining stable weight.
Significant weight loss after a breast cancer diagnosis (more than 10kg) is associated with a much higher risk of death. While weight loss is often seen as positive, unexplained or large weight loss can be a sign of underlying health problems. Survivors should report significant weight loss to their care team to rule out other causes, rather than assuming it is a positive outcome.
women who lost >10 kg had 2.66 times greater mortality (95% CI, 1.73-4.07; Table 3).
Why this rating
Large cohort, long follow-up, adjusted for confounders, but observational.
Source
Body Mass Index Before and After Breast Cancer Diagnosis: Associations with All-Cause, Breast Cancer, and Cardiovascular Disease Mortality
Hazel B. Nichols et al. · Cancer Epidemiology Biomarkers & Prevention · 2009
DOI 10.1158/1055-9965.epi-08-1094
More from this paper
- Post-diagnosis weight gain of >10 kg is associated with a 70% increase in all-cause mortality and a 78% increase in breast cancer-specific mortality compared to maintaining stable weight.Good
- Post-diagnosis obesity (BMI >= 30 kg/m2) is associated with a 52% increase in all-cause mortality and a 2.28 times greater risk of breast cancer-specific mortality compared to normal BMI.Good
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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