Research
Hormonal
Metformin therapy reduces the risk of type 2 diabetes in prediabetic adults by 45%, with greater benefits in those with higher baseline BMI.
If lifestyle changes alone are not enough to prevent diabetes, especially if you have a higher BMI, your doctor may prescribe metformin. It is a safe and effective medication that can help reduce your risk of developing type 2 diabetes.
GoodSupportsHIGH confidence
Lily and Godwin concluded after a systematic review of the literature and meta-analysis that metformin lowers risk of Type 2 diabetes by 45%.
Why this rating
Based on systematic reviews and meta-analyses, but less robust than lifestyle intervention data.
Source
Prediabetes and Lifestyle Modification: Time to Prevent a Preventable Disease
Phillip Tuso · The Permanente Journal · 2014
DOI 10.7812/tpp/14-002
narrative_reviewCited 255×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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