Energy balance
Long-term moderate calorie restriction (25% reduction) significantly reduces circulating inflammatory markers (CRP, TNF-α, WBC, leptin) in non-obese adults without impairing cell-mediated immunity.
If you are a healthy, non-obese adult, reducing your daily calorie intake by 25% for two years significantly lowers your systemic inflammation (a key driver of aging and chronic disease) without weakening your immune system. Ensure you meet micronutrient needs, potentially with supplements, to support this long-term change.
long-term moderate CR without malnutrition induces a significant and persistent inhibition of inflammation without impairing key in vivo indicators of cell-mediated immunity.
Why this rating
Multi-center, randomized controlled trial (RCT) with a large sample size (n=218) and long duration (24 months).
Source
Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans
Simin Nikbin Meydani et al. · Aging · 2016
DOI 10.18632/aging.100994
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →