Macro partitioning
Replacing dietary carbohydrates with saturated fats reduces the risk of stroke and all-cause mortality, whereas replacing carbohydrates with unsaturated fats or animal-derived proteins increases mortality risk.
If you are currently eating a high-carbohydrate diet, consider replacing some of those refined carbs with plant-based fats (like those from nuts or seeds) rather than animal fats. This substitution has been linked to a lower risk of stroke and mortality in large population studies, challenging the old advice to simply cut all fat.
Isocaloric (5% energy) substitution of carbohydrate with saturated fatty acids reduced the risk of stroke by 20% [23]. ... Replacing carbohydrates with plant-based fat and protein was found to reduce the risk of mortality, but animal-derived fat and protein had opposite effects [26].
Why this rating
Based on a large observational study (PURE) which the authors themselves acknowledge has limitations regarding the reliability of food frequency questionnaires and baseline-only assessment.
Source
Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review
Jibran A. Wali et al. · Nutrients · 2020
DOI 10.3390/nu12051505
More from this paper
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Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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