Research
Macro partitioning
Higher circulating levels of linoleic acid (LA) are specifically associated with a ~50% lower risk of non-arrhythmic coronary heart disease (CHD) mortality, while other omega-6 fatty acids (AA, GLA, DGLA) show no significant association with mortality.
If you consume linoleic acid (LA) through vegetable oils, it is specifically linked to a significantly lower risk of dying from non-arrhythmic heart disease. Other omega-6 fats like Arachidonic Acid (AA) do not show this protective effect, highlighting that not all omega-6s are the same.
GoodSupportsHIGH confidence
Among CVD subtypes, LA most strongly associated with non-arrhythmic CHD mortality, with 49% lower risk across quintiles (P for trend=0.001)... Circulating GLA, DGLA, and AA were not significantly associated with total or cause-specific mortality.
Why this rating
Strong association with a specific endpoint, but observational nature.
Source
Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality
Jason Wu et al. · Circulation · 2014
DOI 10.1161/circulationaha.114.011590
cohort · n=2792Cited 198×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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