Research

Energy balance

Low baseline rates of energy expenditure and low fat oxidation predict future body weight gain, and low fat oxidation specifically predicts weight gain independently of energy expenditure.

If you tend to burn fewer calories at rest or prefer burning carbohydrates over fat, you may be predisposed to gain weight. This is a biological risk factor, not a moral failing. Awareness of this can help you tailor your diet and activity to counteract these tendencies.

GoodSupportsHIGH confidence
Several (2–7), but not all (8 –10), prospective studies have shown that a relatively low energy expenditure (2–5) and a relatively high respiratory quotient, i.e. a low fat to carbohydrate oxidation rate (6, 7) predict body weight gain.
Christian Weyer et al. · The Journal of Clinical Endocrinology & Metabolism · 2000

Why this rating

Based on multiple prospective studies cited and the current longitudinal data confirming the relationship.

Source

Energy Expenditure, Fat Oxidation, and Body Weight Regulation: A Study of Metabolic Adaptation to Long- Term Weight Change

Christian Weyer et al. · The Journal of Clinical Endocrinology & Metabolism · 2000

DOI 10.1210/jcem.85.3.6447

cohort · n=102Cited 152×
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DOI resolved against Crossref · corpus check 2026-06-10

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