Mixed
Training to volitional failure, contraction velocity, set configuration, inter-set rest, periodization, time of day, and exercise order do not significantly influence skeletal muscle hypertrophy.
You do not need to obsess over training to failure, specific tempos, exercise order, or rest periods to build muscle. These variables have little to no impact on hypertrophy compared to the main drivers: load, frequency, and volume. Choose what is sustainable for you.
There was insufficient evidence to conclude that time of day, periodization, inter-set rest, set configuration, set end point, contraction velocity/time under tension, or exercise order (only pertaining to hypertrophy) influenced skeletal muscle adaptations.
Why this rating
Based on 'insufficient evidence' across multiple reviews for these variables.
Source
The influence of resistance exercise training prescription variables on skeletal muscle mass, strength, and physical function in healthy adults: An umbrella review
Jonathan C. Mcleod et al. · Journal of sport and health science/Journal of Sport and Health Science · 2023
DOI 10.1016/j.jshs.2023.06.005
More from this paper
- Resistance training increases skeletal muscle mass, strength, and physical function in healthy adults compared to no exercise.Good
- Resistance training load (intensity) and weekly frequency impact muscular strength gains, whereas volume (number of sets) influences both strength and hypertrophy.Good
- Resistance training load (intensity) does not significantly impact skeletal muscle hypertrophy, provided sets are performed to or near volitional fatigue.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →