Energy balance
Weight loss of 10% or greater is associated with clinically significant improvements in asthma control (ACQ scores) in obese adults with uncontrolled asthma, whereas modest weight loss (<10%) is not.
For obese individuals with uncontrolled asthma, losing 10% or more of their body weight is likely to result in meaningful improvements in asthma control. Losing less than 10% may not provide enough benefit to change asthma symptoms, even if it helps other health markers. This suggests that asthma management in obesity may require more aggressive weight loss strategies than standard lifestyle advice.
Among all participants regardless of treatment assignment, weight loss of 10% or greater was associated with a Cohen d effect of 0.76 and with 3.78 (95% confidence interval, 1.72–8.31) times the odds of achieving clinically significant reductions (i.e., >0.5) on ACQ as stable weight (<3% loss or gain from baseline).
Why this rating
Derived from the same rigorous RCT, using subgroup analysis of all participants.
Source
Behavioral Weight Loss and Physical Activity Intervention in Obese Adults with Asthma. A Randomized Trial
Jun Ma et al. · Annals of the American Thoracic Society · 2014
DOI 10.1513/annalsats.201406-271oc
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