Energy balance
The doubly labeled water method slightly underestimates energy expenditure in heavier and fatter subjects compared to respiratory gas exchange, likely due to larger sequestration of isotopes in fat synthesis.
If you are using doubly labeled water to measure your energy needs, be aware that the device may slightly underestimate your true expenditure if you have a high body fat percentage. This is likely due to isotopes being sequestered in fat synthesis. For leaner individuals, the method is highly accurate.
The doubly labeled water method is a suitable and accurate method to measure energy expenditure in free-living conditions... However, we also showed that a slightly larger underestimate was found in the heavier or fatter subjects... The underestimation in heavier subjects might be related to larger sequestration of deuterium labeled water in fatter subjects.
Why this rating
High-quality validation study with controlled conditions and direct comparison to gold-standard respiratory chambers.
Source
Energy expenditure by doubly labeled water: validation in lean and obese subjects
Éric Ravussin et al. · American Journal of Physiology-Endocrinology and Metabolism · 1991
DOI 10.1152/ajpendo.1991.261.3.e402
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