Hormonal
Performing resistance exercise immediately after endurance exercise enhances Akt phosphorylation (a key anabolic signaling pathway) compared to performing resistance exercise alone, whereas performing endurance exercise after resistance exercise does not augment this response.
If you combine cardio and weights in one session, the order changes your body's molecular signals. Doing resistance training after cardio may actually boost Akt signaling (a growth pathway) more than doing resistance alone. However, this doesn't mean all growth pathways are boosted; other markers like mTOR targets showed different patterns. Don't stress about order for every goal, but be aware that 'interference' is complex and order-dependent.
However, an initial bout of cycling did not prevent an exercise-induced increase in phosphorylation from rest when a subsequent bout of resistance exercise was performed (REX2, P < 0.002), and REX2 resulted in a greater change from rest than REX1 (+55%, ES = 0.8; Fig. 2A).
Why this rating
Randomized crossover design with rigorous molecular analysis, but small sample size (n=8) and acute timeframe limit generalizability to chronic adaptations.
Source
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Vernon G. Coffey et al. · Journal of Applied Physiology · 2009
DOI 10.1152/japplphysiol.91221.2008
More from this paper
- Performing resistance exercise before endurance exercise exacerbates the transcriptional response of muscle atrophy genes (MuRF) compared to performing endurance exercise before resistance.Good
- Performing endurance exercise before resistance exercise attenuates the mRNA response of IGF-IEa (a growth factor) compared to performing resistance exercise before endurance exercise.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →