Hormonal
Performing resistance exercise before endurance exercise exacerbates the transcriptional response of muscle atrophy genes (MuRF) compared to performing endurance exercise before resistance.
If you do resistance training before cardio, your body may upregulate genes associated with muscle breakdown (MuRF) more than if you do cardio first. This suggests that 'weights first' might have a catabolic cost in terms of specific gene expression, even if it boosts growth signals like Akt. Balance your training to manage these competing signals.
Moreover, changes in delta mRNA abundance indicate that MuRF transcriptional activity was exacerbated when cycling was undertaken after resistance exercise (REX1-CYC2 vs. CYC1-REX2, +52%, ES = 0.4).
Why this rating
Same study strengths/limitations as N1. The finding is statistically significant but the effect size is moderate.
Source
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Vernon G. Coffey et al. · Journal of Applied Physiology · 2009
DOI 10.1152/japplphysiol.91221.2008
More from this paper
- Performing resistance exercise immediately after endurance exercise enhances Akt phosphorylation (a key anabolic signaling pathway) compared to performing resistance exercise alone, whereas performing endurance exercise after resistance exercise does not augment this response.Good
- Performing endurance exercise before resistance exercise attenuates the mRNA response of IGF-IEa (a growth factor) compared to performing resistance exercise before endurance exercise.Good
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