Research
Adherence
Combining incretin-mimetic drug therapy with resistance training and adequate protein intake minimizes skeletal muscle loss and preserves metabolic health.
To keep your muscle while losing weight on GLP-1 drugs, you must lift weights at least twice a week and eat enough protein (aim for 1.0-1.5g per kg of your goal weight). This combination is the only way to ensure the weight you lose comes from fat, not muscle.
GoodSupportsHIGH confidence
Concurrent physical activity, especially resistance training, has been shown to effectively minimize loss of muscle mass and function during weight reduction therapy.
Why this rating
Supported by systematic reviews, meta-analyses, and clinical trials cited in the paper.
Source
Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity
Jeffrey I. Mechanick et al. · Obesity Reviews · 2024
narrative_reviewCited 111×
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