Research
Mixed
Oral nutritional supplements (ONS) containing high-quality protein and micronutrients are an effective strategy to prevent nutrient deficiencies and support muscle health in patients with reduced appetite from IMDs.
If you can't eat enough protein due to nausea or fullness from your medication, use oral nutritional supplements (ONS) to fill the gap. Choose products specifically designed for muscle health, not just isolated vitamin pills.
ModerateSupportsMEDIUM confidence
If patients receiving IMD therapy are unable to maintain a diet containing sufficient high-quality protein and micronutrients, oral nutritional supplements (ONS) may be an effective and scalable option.
Why this rating
Supported by guidelines and trials, but specific long-term data in young obese adults on IMDs is noted as ongoing.
Source
Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity
Jeffrey I. Mechanick et al. · Obesity Reviews · 2024
DOI 10.1111/obr.13841
narrative_reviewCited 111×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Incretin-mimetic drugs (IMDs) such as semaglutide and tirzepatide cause significant skeletal muscle mass loss (≥10%) during rapid weight reduction, a loss comparable to 20 years of age-related decline.Good
- Combining incretin-mimetic drug therapy with resistance training and adequate protein intake minimizes skeletal muscle loss and preserves metabolic health.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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