Macro partitioning

Isocaloric substitution of total fat or saturated fatty acids (SFA) with other macronutrients (carbohydrates, proteins, or other fats) does not significantly alter the risk of cardiovascular disease.

Replacing saturated fats with carbohydrates, proteins, or other fats does not appear to significantly change the risk of cardiovascular disease, according to this study. This suggests that rigid substitution rules may not be necessary, and a balanced approach to macronutrient intake might be more sustainable.