Research
Macro partitioning
Isocaloric substitution of total fat or saturated fatty acids (SFA) with other macronutrients (carbohydrates, proteins, or other fats) does not significantly alter the risk of cardiovascular disease.
Replacing saturated fats with carbohydrates, proteins, or other fats does not appear to significantly change the risk of cardiovascular disease, according to this study. This suggests that rigid substitution rules may not be necessary, and a balanced approach to macronutrient intake might be more sustainable.
GoodRefutesHIGH confidence
Substitutions of total fats or SFA with other macronutrients were not associated with CVD risk.
Why this rating
Same high-quality cohort study with substitution analysis.
Source
The association between dietary fats and the incidence risk of cardiovascular outcomes: Tehran Lipid and Glucose Study
Zahra Gaeini et al. · Nutrition & Metabolism · 2021
DOI 10.1186/s12986-021-00624-6
cohort · n=2809Cited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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